Article
Deoxycholic acid (DCA) confers an intestinal phenotype on esophageal squamous epithelium via induction of the stemness-associated reprogramming factors OCT4 and SOX2.
Cell cycle (Georgetown, Tex.) - 2 Jun 2016
Shen Caifei, Zhang Haoxiang, Wang Pu, Feng Ji, Li Jingwen, Xu Yin, Zhang Anran, Shao Shunzi, Yu Xiaona, Yan Wu, Xia Yiju, Hu Jiali, Fang Dianchun
Abstract excerpt
Barrett's esophagus (BE) is essentially a metaplasia in which the normal stratified squamous epithelium is replaced by columnar epithelium. This study focuses on the involvement of OCT4 and SOX2, 2 key cell-reprogramming factors, in the deoxycholic acid (DCA)-induced expression of the intestinal hallmarks Cdx2 and MUC2 using both in vivo and in vitro models. Up-regulated expression of OCT4 and down-regulated...
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