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Article

Bile Exposure Inhibits Expression of Squamous Differentiation Genes in Human Esophageal Epithelial Cells

12 Apr 2012

Abstract excerpt

OBJECTIVE: This study aimed to identify pathways and cellular processes that are modulated by exposure of normal esophageal cells to bile and acid. BACKGROUND: Barrett's esophagus most likely develops as a response of esophageal stem cells to the abnormal reflux environment. Although insights into the underlying molecular mechanisms are slowly emerging, much of the metaplastic process remains unknown. METHODS: We...

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PMID: 22498892
DOI: 10.1097/sla.0b013e3182512af9

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