Article

GATA4, expressed in Barrett’s esophagus and esophageal adenocarcinoma, can block squamous epithelial cell gene expression in human esophageal cells

2020-06-18

Abstract excerpt

<h4>ABSTRACT</h4> Metaplasia often involves a change from one cell type to another that was present during organogenesis. The embryonic esophagus is initially lined by columnar cells that are replaced by squamous cells, and metaplasia in Barrett’s esophagus (BE) involves a change from squamous to columnar cells in the setting of gastroesophageal reflux. Here, we explored the effect of ectopic expression of the es...

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Literature Corpus work: 136fd74b-bd27-5f1a-b5dd-1218bade4936
DOI: 10.1101/2020.06.17.156026

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