Article
Drug metabolism by flavin-containing monooxygenases of human and mouse.
Expert opinion on drug metabolism & toxicology - 1 Feb 2017
Phillips Ian R, Shephard Elizabeth A
Abstract excerpt
INTRODUCTION: Flavin-containing monooxygenases (FMOs) play an important role in drug metabolism. Areas covered: We focus on the role of FMOs in the metabolism of drugs in human and mouse. We describe FMO genes and proteins of human and mouse; the catalytic mechanism of FMOs and their significance for drug metabolism; differences between FMOs and CYPs; factors contributing to potential underestimation of the...
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