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Article

Human flavin-containing monooxygenases.

Annual review of pharmacology and toxicology - 1 Jan 2006

Cashman John R, Zhang Jun

Abstract excerpt

This review summarizes recent information concerning the pharmacological and toxicological significance of the human flavin-containing monooxygenase (FMO, EC 1.14.13.8). The human FMO oxygenates nucleophilic heteroatom-containing chemicals and drugs and generally converts them into harmless, polar, readily excreted metabolites. Sometimes, however, FMO bioactivates chemicals into reactive materials that can cause...

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Identifiers

PMID: 16402899
DOI: 10.1146/annurev.pharmtox.46.120604.141043

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