Article
Flavin-containing monooxygenase 3 (FMO3): genetic variants and their consequences for drug metabolism and disease
18 Jul 2019
Abstract excerpt
The review focuses on genetic variants of human flavin-containing monooxygenase 3 (FMO3) and their impact on enzyme activity, drug metabolism and disease.The majority of FMO-mediated metabolism in adult human liver is catalyzed by FMO3. Some drugs are metabolized in human liver predominantly by FMO3, but most drug substrates of FMO3 are metabolized also by other enzymes, particularly cytochromes P-450, and the...
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