Article
Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.
The Journal of pharmacology and experimental therapeutics - 1 Nov 2017
Xu Meijuan, Bhatt Deepak Kumar, Yeung Catherine K, Claw Katrina G, Chaudhry Amarjit S, Gaedigk Andrea, Pearce Robin E, Broeckel Ulrich, Gaedigk Roger, Nickerson Deborah A, Schuetz Erin, Rettie Allan E, Leeder J Steven, Thummel Kenneth E, Prasad Bhagwat
Abstract excerpt
Hepatic flavin-containing mono-oxygenase 3 (FMO3) metabolizes a broad array of nucleophilic heteroatom (e.g., N or S)-containing xenobiotics (e.g., amphetamine, sulindac, benzydamine, ranitidine, tamoxifen, nicotine, and ethionamide), as well as endogenous compounds (e.g., catecholamine and trimethylamine). To predict the effect of genetic and nongenetic factors on the hepatic metabolism of FMO3 substrates, we...
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