Article
Human flavin-containing monooxygenase (form 3): polymorphisms and variations in chemical metabolism.
Pharmacogenomics - 1 May 2002
Cashman John R
Abstract excerpt
The human flavin-containing monooxygenases catalyze the oxygenation of nucleophilic heteroatom-containing drugs, xenobiotics and endogenous materials. Evidence for six forms of the FMO gene exist but it is FMO form 3 (FMO3) that is the prominent form in adult human liver that is likely to be associated with the bulk of FMO-mediated metabolism. An understanding of the substrate specificity of human FMO3 is...
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