Article
The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance.
Biochemical pharmacology - 1 Jul 2014
Veeravalli Sunil, Omar Bilal A, Houseman Lyndsey, Hancock Matthew, Gonzalez Malagon Sandra G, Scott Flora, Janmohamed Azara, Phillips Ian R, Shephard Elizabeth A
Abstract excerpt
Flavin-containing monooxygenases (FMOs) of mammals are thought to be involved exclusively in the metabolism of foreign chemicals. Here, we report the unexpected finding that mice lacking Fmos 1, 2 and 4 exhibit a lean phenotype and, despite similar food intake, weigh less and store less triglyceride in white adipose tissue (WAT) than wild-type mice. This is a consequence of enhanced whole-body energy expenditure,...
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