Article
A Novel Tobacco Use Phenotype Suggests the 15q25 and 19q13 Loci May be Differentially Associated With Cigarettes per Day and Tobacco-Related Problems.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 1 Apr 2017
Richmond-Rakerd Leah S, Otto Jacqueline M, Slutske Wendy S, Ehlers Cindy L, Wilhelmsen Kirk C, Gizer Ian R
Abstract excerpt
INTRODUCTION: Tobacco use is associated with variation at the 15q25 gene cluster and the cytochrome P450 (CYP) genes CYP2A6 and CYP2B6. Despite the variety of outcomes associated with these genes, few studies have adopted a data-driven approach to defining tobacco use phenotypes for genetic association analyses. We used factor analysis to generate a tobacco use measure, explored its incremental validity over a...
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