Article
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
Nature genetics - 1 May 2010
Thorgeirsson Thorgeir E, Gudbjartsson Daniel F, Surakka Ida, Vink Jacqueline M, Amin Najaf, Geller Frank, Sulem Patrick, Rafnar Thorunn, Esko Tõnu, Walter Stefan, Gieger Christian, Rawal Rajesh, Mangino Massimo, Prokopenko Inga, Mägi Reedik, Keskitalo Kaisu, Gudjonsdottir Iris H, Gretarsdottir Solveig, Stefansson Hreinn, Thompson John R, Aulchenko Yurii S, Nelis Mari, Aben Katja K, den Heijer Martin, Dirksen Asger, Ashraf Haseem, Soranzo Nicole, Valdes Ana M, Steves Claire, Uitterlinden André G, Hofman Albert, Tönjes Anke, Kovacs Peter, Hottenga Jouke Jan, Willemsen Gonneke, Vogelzangs Nicole, Döring Angela, Dahmen Norbert, Nitz Barbara, Pergadia Michele L, Saez Berta, De Diego Veronica, Lezcano Victoria, Garcia-Prats Maria D, Ripatti Samuli, Perola Markus, Kettunen Johannes, Hartikainen Anna-Liisa, Pouta Anneli, Laitinen Jaana, Isohanni Matti, Huei-Yi Shen, Allen Maxine, Krestyaninova Maria, Hall Alistair S, Jones Gregory T, van Rij Andre M, Mueller Thomas, Dieplinger Benjamin, Haltmayer Meinhard, Jonsson Steinn, Matthiasson Stefan E, Oskarsson Hogni, Tyrfingsson Thorarinn, Kiemeney Lambertus A, Mayordomo Jose I, Lindholt Jes S, Pedersen Jesper Holst, Franklin Wilbur A, Wolf Holly, Montgomery Grant W, Heath Andrew C, Martin Nicholas G, Madden Pamela A F, Giegling Ina, Rujescu Dan, Järvelin Marjo-Riitta, Salomaa Veikko, Stumvoll Michael, Spector Tim D, Wichmann H-Erich, Metspalu Andres, Samani Nilesh J, Penninx Brenda W, Oostra Ben A, Boomsma Dorret I, Tiemeier Henning, van Duijn Cornelia M, Kaprio Jaakko, Gulcher Jeffrey R, McCarthy Mark I, Peltonen Leena, Thorsteinsdottir Unnur, Stefansson Kari
Abstract excerpt
Smoking is a common risk factor for many diseases. We conducted genome-wide association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers (n = 31,266) and smoking initiation (n = 46,481) using samples from the ENGAGE Consortium. In a second stage, we tested selected SNPs with in silico replication in the Tobacco and Genetics (TAG) and Glaxo Smith Kline (Ox-GSK) consortia cohorts (n =...
Read the complete abstract on PubMed