Article
Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.
Nature human behaviour - 1 Jun 2024
Toikumo Sylvanus, Jennings Mariela V, Pham Benjamin K, Lee Hyunjoon, Mallard Travis T, Bianchi Sevim B, Meredith John J, Vilar-Ribó Laura, Xu Heng, Hatoum Alexander S, Johnson Emma C, Pazdernik Vanessa K, Jinwala Zeal, Pakala Shreya R, Leger Brittany S, Niarchou Maria, Ehinmowo Michael, Jenkins Greg D, Batzler Anthony, Pendegraft Richard, Palmer Abraham A, Zhou Hang, Biernacka Joanna M, Coombes Brandon J, Gelernter Joel, Xu Ke, Hancock Dana B, Cox Nancy J, Smoller Jordan W, Davis Lea K, Justice Amy C, Kranzler Henry R, Kember Rachel L, Sanchez-Roige Sandra
Abstract excerpt
Tobacco use disorder (TUD) is the most prevalent substance use disorder in the world. Genetic factors influence smoking behaviours and although strides have been made using genome-wide association studies to identify risk variants, most variants identified have been for nicotine consumption, rather than TUD. Here we leveraged four US biobanks to perform a multi-ancestral meta-analysis of TUD (derived via...
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