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Article

Dissection of the phenotypic and genotypic associations with nicotinic dependence.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 1 Apr 2012

Chen Li-Shiun, Baker Timothy B, Grucza Richard, Wang Jen C, Johnson Eric O, Breslau Naomi, Hatsukami Dorothy, Smith Stevens S, Saccone Nancy, Saccone Scott, Rice John P, Goate Alison M, Bierut Laura J

Abstract excerpt

INTRODUCTION: Strong evidence demonstrates that nicotine dependence is associated with 4 genetic variants rs16969968, rs6474412, rs3733829, and rs1329650 in large-scale Genome-Wide Association Studies. We examined how these identified genetic variants relate to nicotine dependence defined by different categorical and dimensional measures. METHODS: Four genetic variants were analyzed in 2,047 subjects of European...

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Source

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Identifiers

PMID: 22102629
DOI: 10.1093/ntr/ntr231
PMCID: PMC3313785

Genes

CPD
CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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