Article
Exploring the role of low-frequency and rare exonic variants in alcohol and tobacco use.
Drug and alcohol dependence - 1 Jul 2018
Marees Andries T, Hammerschlag Anke R, Bastarache Lisa, de Kluiver Hilde, Vorspan Florence, van den Brink Wim, Smit Dirk J, Denys Damiaan, Gamazon Eric R, Li-Gao Ruifang, Breetvelt Elemi J, de Groot Mark C H, Galesloot Tessel E, Vermeulen Sita H, Poppelaars Jan L, Souverein Patrick C, Keeman Renske, de Mutsert Renée, Noordam Raymond, Rosendaal Frits R, Stringa Najada, Mook-Kanamori Dennis O, Vaartjes Ilonca, Kiemeney Lambertus A, den Heijer Martin, van Schoor Natasja M, Klungel Olaf H, Maitland-Van der Zee Anke H, Schmidt Marjanka K, Polderman Tinca J C, van der Leij Andries R, Posthuma Danielle, Derks Eske M
Abstract excerpt
BACKGROUND: Alcohol and tobacco use are heritable phenotypes. However, only a small number of common genetic variants have been identified, and common variants account for a modest proportion of the heritability. Therefore, this study aims to investigate the role of low-frequency and rare variants in alcohol and tobacco use. METHODS: We meta-analyzed ExomeChip association results from eight discovery cohorts and...
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