Article
Meta-analysis and imputation refines the association of 15q25 with smoking quantity.
Nature genetics - 1 May 2010
Liu Jason Z, Tozzi Federica, Waterworth Dawn M, Pillai Sreekumar G, Muglia Pierandrea, Middleton Lefkos, Berrettini Wade, Knouff Christopher W, Yuan Xin, Waeber Gérard, Vollenweider Peter, Preisig Martin, Wareham Nicholas J, Zhao Jing Hua, Loos Ruth J F, Barroso Inês, Khaw Kay-Tee, Grundy Scott, Barter Philip, Mahley Robert, Kesaniemi Antero, McPherson Ruth, Vincent John B, Strauss John, Kennedy James L, Farmer Anne, McGuffin Peter, Day Richard, Matthews Keith, Bakke Per, Gulsvik Amund, Lucae Susanne, Ising Marcus, Brueckl Tanja, Horstmann Sonja, Wichmann H-Erich, Rawal Rajesh, Dahmen Norbert, Lamina Claudia, Polasek Ozren, Zgaga Lina, Huffman Jennifer, Campbell Susan, Kooner Jaspal, Chambers John C, Burnett Mary Susan, Devaney Joseph M, Pichard Augusto D, Kent Kenneth M, Satler Lowell, Lindsay Joseph M, Waksman Ron, Epstein Stephen, Wilson James F, Wild Sarah H, Campbell Harry, Vitart Veronique, Reilly Muredach P, Li Mingyao, Qu Liming, Wilensky Robert, Matthai William, Hakonarson Hakon H, Rader Daniel J, Franke Andre, Wittig Michael, Schäfer Arne, Uda Manuela, Terracciano Antonio, Xiao Xiangjun, Busonero Fabio, Scheet Paul, Schlessinger David, St Clair David, Rujescu Dan, Abecasis Gonçalo R, Grabe Hans Jörgen, Teumer Alexander, Völzke Henry, Petersmann Astrid, John Ulrich, Rudan Igor, Hayward Caroline, Wright Alan F, Kolcic Ivana, Wright Benjamin J, Thompson John R, Balmforth Anthony J, Hall Alistair S, Samani Nilesh J, Anderson Carl A, Ahmad Tariq, Mathew Christopher G, Parkes Miles, Satsangi Jack, Caulfield Mark, Munroe Patricia B, Farrall Martin, Dominiczak Anna, Worthington Jane, Thomson Wendy, Eyre Steve, Barton Anne, Mooser Vincent, Francks Clyde, Marchini Jonathan
Abstract excerpt
Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that...
