Article
Dissecting the genetic overlap of smoking behaviors, lung cancer, and chronic obstructive pulmonary disease: A focus on nicotinic receptors and nicotine metabolizing enzyme.
Genetic epidemiology - 1 Oct 2020
Bray Michael J, Chen Li-Shiun, Fox Louis, Hancock Dana B, Culverhouse Robert C, Hartz Sarah M, Johnson Eric O, Liu Mengzhen, McKay James D, Saccone Nancy L, Hokanson John E, Vrieze Scott I, Tyndale Rachel F, Baker Timothy B, Bierut Laura J
Abstract excerpt
Smoking is a major contributor to lung cancer and chronic obstructive pulmonary disease (COPD). Two of the strongest genetic associations of smoking-related phenotypes are the chromosomal regions 15q25.1, encompassing the nicotinic acetylcholine receptor subunit genes CHRNA5-CHRNA3-CHRNB4, and 19q13.2, encompassing the nicotine metabolizing gene CYP2A6. In this study, we examined genetic relations between...
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