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Article

Association of CYP2C19 variants and epoxyeicosatrienoic acids on patients with microvascular angina.

American journal of physiology. Heart and circulatory physiology - 1 Dec 2016

Akasaka Tomonori, Sueta Daisuke, Arima Yuichiro, Tabata Noriaki, Takashio Seiji, Izumiya Yasuhiro, Yamamoto Eiichiro, Yamamuro Megumi, Tsujita Kenichi, Kojima Sunao, Kaikita Koichi, Kajiwara Ayami, Morita Kazunori, Oniki Kentaro, Saruwatari Junji, Nakagawa Kazuko, Ogata Yasuhiro, Matsui Kunihiko, Hokimoto Seiji

Abstract excerpt

Categorization as a cytochrome P450 (CYP) 2C19 poor metabolizer (PM) is reported to be an independent risk factor for cardiovascular disease. Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by CYP2C19 epoxygenases and anti-inflammatory properties, especially in microvascular tissues. We examined the association of CYP2C19 polymorphisms and EETs on microvascular angina (MVA) caused by coronary...

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PMID: 27663770
DOI: 10.1152/ajpheart.00473.2016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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