Article
Association between cytochrome P450 2C19 polymorphism and clinical outcomes in Chinese patients with coronary artery disease.
Atherosclerosis - 1 Jan 2012
Chen Mao, Liu Xiao-Jing, Yan Shao-Di, Peng Yong, Chai Hua, Li Qiao, Wei Jia-Fu, Xu Yuan-Ning, Huang De-Jia
Abstract excerpt
BACKGROUND: Cytochrome P450 (CYP)2C19 is expressed in vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids, which play a key role in regulating vascular tone. The aim of this study was to investigate whether the genetic functional variant 681G>A (*2) of cytochrome CYP2C19 is associated with adverse cardiovascular outcomes in Chinese patients with coronary artery...
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