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Article

Role of CYP2C9 and CYP2C19 polymorphisms in patients with atherosclerosis.

Cell biochemistry and function - 1 Apr 2008

Ercan B, Ayaz L, Ciçek D, Tamer L

Abstract excerpt

The arachidonic acid metabolizing CYP enzymes with prominent roles in vascular regulation are epoxygenases of the two gene family which generate epoxyeicosatrienoic acids. Carriers of CYP2C9 mutant alleles exhibit a diminished CYP2C9 metabolic capacity leading to decreased endothelium-derived hyperpolarizing factors (EDHF) synthesis and an increased risk for atherosclerosis. We investigated whether the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17868191
DOI: 10.1002/cbf.1437

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