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Article

Sex differences in the impact of CYP2C19 polymorphisms and low-grade inflammation on coronary microvascular disorder.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2016

Akasaka Tomonori, Hokimoto Seiji, Sueta Daisuke, Tabata Noriaki, Sakamoto Kenji, Yamamoto Eiichiro, Yamamuro Megumi, Tsujita Kenichi, Kojima Sunao, Kaikita Koichi, Kajiwara Ayami, Morita Kazunori, Oniki Kentaro, Saruwatari Junji, Nakagawa Kazuko, Ogata Yasuhiro, Ogawa Hisao

Abstract excerpt

Categorization as a cytochrome P-450 (CYP) 2C19 poor metabolizer (PM) is reported to be an independent risk factor for cardiovascular disease. It is correlated with an increase in the circulating levels of high-sense C-reactive protein (hs-CRP) in women only, although its role in coronary microcirculation is unclear. We examined sex differences in the impact of the CYP2C19 genotype and low-grade inflammation on...

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PMID: 26993229
DOI: 10.1152/ajpheart.00911.2015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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