Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variance in CYP2C8 and increased risk of myocardial infarction.

Pharmacogenetics and genomics - 1 Jul 2010

Rodenburg Eline M, Visser Loes E, Danser A H Jan, Hofman Albert, van Noord Charlotte, Witteman Jacqueline C M, Uitterlinden André G, Stricker Bruno H Ch

Abstract excerpt

BACKGROUND: Epoxyeicosatrienoic acids (EETs) are important mediators in vasodilatation, acting as endothelium-derived hyperpolarizing factors. CYP2C enzymes catalyze the metabolism of arachidonic acid to EETs. Genetic variation within the genes encoding for these enzymes may result in differences in vascular response, among others in myocardial tissue, and may therefore increase the risk of myocardial infarction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Hydroxylases
Share to Chromosomes, Human, Pair 10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C8

Share to Cytochrome P-450 CYP2C9

Share to Myocardial Infarction

Share to Netherlands

Share to Proportional Hazards Models

Share to Sex Characteristics

Source

Identifiers

PMID: 20436375
DOI: 10.1097/FPC.0b013e32833a96d8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variance in CYP2C8 and increased risk of myocardial infarction.PMID 20436375Read ↗

Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke.Semantic proximity Read ↗

Association of CYP2C8, CYP2C9 and CYP2J2 gene polymorphisms with myocardial infarction in South Indian population.Semantic proximity Read ↗

Allelic variants of cytochromes P450 2C modify the risk for acute myocardial infarction.Semantic proximity Read ↗

Polymorphisms of CYP2C8, CYP2C9 and CYP2C19 and risk of coronary heart disease in Russian population.Semantic proximity Read ↗

The CYP2J2 G-50T polymorphism and myocardial infarction in patients with cardiovascular risk profile.Semantic proximity Read ↗

Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myocardial infarction.Semantic proximity Read ↗

Genetic variation in the cytochrome P450 epoxygenase pathway and cardiovascular disease risk.Semantic proximity Read ↗

CYP2C9*2 and CYP2C9*3 alleles confer a lower risk for myocardial infarction.Semantic proximity Read ↗

Impact of CYP2C8 and 2C9 polymorphisms on coronary artery disease and myocardial infarction in the LURIC cohort.Semantic proximity Read ↗

Association between ESR2 genetic variants and risk of myocardial infarction.Semantic proximity Read ↗

The risk of myocardial infarction in patients with reduced activity of cytochrome P450 2C9.Semantic proximity Read ↗

Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.