Article
Association of CYP2C8, CYP2C9 and CYP2J2 gene polymorphisms with myocardial infarction in South Indian population.
Pharmacological reports : PR - 1 Feb 2015
Arun Kumar Annan Sudarsan, Kumar Srinivasamurthy Suresh, Umamaheswaran Gurusamy, Kesavan Ramasamy, Balachandar Jayaraman, Adithan Chandrasekaran
Abstract excerpt
BACKGROUND: Cardiovascular diseases (CVDs) are the major cause of mortality and morbidity worldwide. Myocardial infarction (MI) is a complex multi-factorial, polygenic disorder arising from an interaction between genetic makeup of individuals and various environmental factors. CYP2C8, CYP2C9 and CYP2J2 gene involved in the metabolism of arachidonic acid, generates epoxyeicosatrienoic acids (EETs) that mediate...
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