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Article

Role and therapeutic potential of CDK12 in human cancers.

Cancer treatment reviews - 1 Nov 2016

Chilà Rosaria, Guffanti Federica, Damia Giovanna

Abstract excerpt

Phosphorylation of the RNA polymerase II C-terminal domain by cyclin-dependent kinases (CDKs) is important for productive transcription. Deregulated transcription-CDKs have been reported in different human cancers. Until recently CDK9 was the only transcription-CDK with a causative role in cancer, but evidence is cumulating of the importance of CDK12. This review summarizes the role of CDK12 in transcription and...

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Source

Identifiers

PMID: 27662623
DOI: 10.1016/j.ctrv.2016.09.003

Genes

CDK12
CDK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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