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Article

CDK12: an emerging therapeutic target for cancer.

Journal of clinical pathology - 1 Nov 2018

Lui Goldie Y L, Grandori Carla, Kemp Christopher J

Abstract excerpt

Cyclin-dependent kinase 12 (CDK12) belongs to the cyclin-dependent kinase (CDK) family of serine/threonine protein kinases that regulate transcriptional and post-transcriptional processes, thereby modulating multiple cellular functions. Early studies characterised CDK12 as a transcriptional CDK that complexes with cyclin K to mediate gene transcription by phosphorylating RNA polymerase II. CDK12 has been...

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Share to Antineoplastic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30104286
DOI: 10.1136/jclinpath-2018-205356
PMCID: PMC6242340

Genes

CDK12
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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