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CDK12: A Potent Target and Biomarker for Human Cancer Therapy

18 Jun 2020

Abstract excerpt

Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcription, RNA splicing, translation, DNA damage response (DDR), cell cycle progression and cell...

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PMID: 32570740
DOI: 10.3390/cells9061483

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