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The Emerging Picture of CDK11: Genetic, Functional and Medicinal Aspects

17 Aug 2017

Abstract excerpt

Cyclin-dependent kinase 11 is a relatively neglected member of the transcriptional CDKs subfamily, despite possibly being the most versatile CDK in this group. Different CDK11 variants are known to play essential roles in major cellular processes as mRNA transcription (CDK11p110), mitosis (CDK11p58), and apoptosis (CDK11p46 and CDK11p60). Each CDK11 species targets a particular set of substrates related to its...

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PMID: 28814241
DOI: 10.2174/0929867324666170815102036

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