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Article

[Function of CDK12 in Tumor initiation and progression and its clinical consequences].

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti - 1 Jan 2014

Vrábel D, Svoboda M, Navrátil J, Kohoutek J

Abstract excerpt

Cyclin-dependent kinases (CDKs) participate in many cellular processes and play a crucial role in the regulation of cell cycle and transcription processes. Recently, CDK12 was identified as a key factor orchestrating transcription of genes, such as BRCA1, ATM, ATR, FANCI and FANCD2, which are involved in the DNA-damage response pathway. Importantly, inhibition of function of these genes commonly leads to...

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Source

Identifiers

PMID: 25312711
DOI: 10.14735/amko2014340

Genes

CDK12
ATM
ATR
BRCA1
FANCD2
FANCI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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