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A Phenotypic High-Content Screening Assay to Identify Regulators of Membrane Protein Localization.

Assay and drug development technologies - 1 Oct 2016

Smith Lorey K, Thomas Daniel W, Simpson Kaylene J, Humbert Patrick O

Abstract excerpt

Correct subcellular localization of proteins is a requirement for appropriate function. This is especially true in epithelial cells, which rely on the precise localization of a diverse array of epithelial polarity and cellular adhesion proteins. Loss of cell polarity and adhesion is a hallmark of cancer, and mislocalization of core polarity proteins, such as Scribble, is observed in a range of human epithelial...

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Identifiers

PMID: 27661290
DOI: 10.1089/adt.2016.733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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