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Article

Identification of genes that regulate epithelial cell migration using an siRNA screening approach.

Nature cell biology - 1 Sept 2008

Simpson Kaylene J, Selfors Laura M, Bui James, Reynolds Angela, Leake Devin, Khvorova Anastasia, Brugge Joan S

Abstract excerpt

To provide a systematic analysis of genes that regulate epithelial cell migration, we performed a high throughput wound healing screen with MCF-10A breast epithelial cells, using siRNAs targeting 1,081 human genes encoding phosphatases, kinases and proteins predicted to influence cell migration and adhesion. The primary screen identified three categories of hits: those that accelerate, those that inhibit and...

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PMID: 19160483
DOI: 10.1038/ncb1762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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