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Selection of Optimal Cell Lines for High-Content Phenotypic Screening.

ACS chemical biology - 21 Apr 2023

Heinrich Louise, Kumbier Karl, Li Li, Altschuler Steven J, Wu Lani F

Abstract excerpt

High-content microscopy offers a scalable approach to screen against multiple targets in a single pass. Prior work has focused on methods to select "optimal" cellular readouts in microscopy screens. However, methods to select optimal cell line models have garnered much less attention. Here, we provide a roadmap for how to select the cell line or lines that are best suited to identify bioactive compounds and their...

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Cell Line
Drug Discovery
Phenotype

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36920184
DOI: 10.1021/acschembio.2c00878
PMCID: PMC10127200

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