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Article

A robust high-content imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators.

Molecular cancer therapeutics - 1 Feb 2011

Sutherland Jeffrey J, Low Jonathan, Blosser Wayne, Dowless Michele, Engler Thomas A, Stancato Louis F

Abstract excerpt

High-content screening is increasingly used to elucidate changes in cellular biology arising from treatment with small molecules and biological probes. We describe a cell classifier for automated analysis of multiparametric data from immunofluorescence microscopy and characterize the phenotypes of 41 cell-cycle modulators, including several protein kinase inhibitors in preclinical and clinical development. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21216932
DOI: 10.1158/1535-7163.MCT-10-0720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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