Article
Noise genetics: inferring protein function by correlating phenotype with protein levels and localization in individual human cells.
PLoS genetics - 1 Mar 2014
Farkash-Amar Shlomit, Zimmer Anat, Eden Eran, Cohen Ariel, Geva-Zatorsky Naama, Cohen Lydia, Milo Ron, Sigal Alex, Danon Tamar, Alon Uri
Abstract excerpt
To understand gene function, genetic analysis uses large perturbations such as gene deletion, knockdown or over-expression. Large perturbations have drawbacks: they move the cell far from its normal working point, and can thus be masked by off-target effects or compensation by other genes. Here, we offer a complementary approach, called noise genetics. We use natural cell-cell variations in protein level and...
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