Article

Expanding the Landscape of Aging via Orbitrap Astral Mass Spectrometry and Tandem Mass Tag (TMT) Integration

2024-12-20

Abstract excerpt

Aging results in a progressive decline in physiological function due to the deterioration of essential biological processes, such as transcription and RNA splicing, ultimately increasing mortality risk. Although proteomics is emerging as a powerful tool for elucidating the molecular mechanisms of aging, existing studies are constrained by limited proteome coverage and only observe a narrow range of lifespan. To ov...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c4924b74-8018-5f10-b0f9-9910c17f4703
DOI: 10.1101/2024.12.13.628374

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Expanding the Landscape of Aging via Orbitrap Astral Mass Spectrometry and Tandem Mass Tag (TMT) IntegrationDOI 10.1101/2024.12.13.628374Read

Circulating extracellular vesicles in plasma carry accessible molecular signatures of aging in miceSemantic proximity Read

Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegenerationSemantic proximity Read

Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signaturesSemantic proximity Read

Proteomics and Epidemiological Models of Human AgingSemantic proximity Read

Ontological Analysis of Brain Proteostasis Highlights the Sex-Dependent Trajectory of ApoE Isoform-Specific RegulationSemantic proximity Read

Fast and Deep Phosphoproteome Analysis with the Orbitrap Astral Mass SpectrometerSemantic proximity Read

Proteomic Atlas of the Human Brain in Alzheimer’s DiseaseSemantic proximity Read

Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvementSemantic proximity Read

Temporal and Sex-Linked Protein Expression Dynamics in a Familial Model of Alzheimer’s DiseaseSemantic proximity Read

Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease.Semantic proximity Read

Domain-specific proteome remodeling defines mouse myelin agingSemantic proximity Read

What have we learned on aging from omics studies?Semantic proximity Read