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Article

Quantitative mass spectrometry identifies insulin signaling targets in C. elegans.

Science (New York, N.Y.) - 3 Aug 2007

Dong Meng-Qiu, Venable John D, Au Nora, Xu Tao, Park Sung Kyu, Cociorva Daniel, Johnson Jeffrey R, Dillin Andrew, Yates John R

Abstract excerpt

DAF-2, an insulin receptor-like protein, regulates metabolism, development, and aging in Caenorhabditis elegans. In a quantitative proteomic study, we identified 86 proteins that were more or less abundant in long-lived daf-2 mutant worms than in wild-type worms. Genetic studies on a subset of these proteins indicated that they act in one or more processes regulated by DAF-2, including entry into the dauer...

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Identifiers

PMID: 17673661
DOI: 10.1126/science.1139952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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