Article
Evidence that COMT genotype and proline interact on negative-symptom outcomes in schizophrenia and bipolar disorder.
Translational psychiatry - 13 Sept 2016
Clelland C L, Drouet V, Rilett K C, Smeed J A, Nadrich R H, Rajparia A, Read L L, Clelland J D
Abstract excerpt
Elevated peripheral proline is associated with psychiatric disorders, and there is evidence that proline is a neuromodulator. The proline dehydrogenase (PRODH) gene, which encodes the enzyme that catalyzes proline catabolism, maps to human chromosome 22q11.2, a region conferring risk of schizophrenia. In the Prodh-null mouse, an interaction between elevated peripheral proline and another 22q11.2 gene,...
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