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Article

Catechol-O-methyltransferase and the clinical features of psychosis.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Dec 2006

McClay J L, Fanous A, van den Oord E J C G, Webb B T, Walsh D, O'Neill F A, Kendler K S, Chen X

Abstract excerpt

A functional polymorphism (Val-158-Met) at the Catechol-O-methyltransferase (COMT) locus has been identified as a potential etiological factor in schizophrenia. Yet the association has not been convincingly replicated across independent samples. We hypothesized that phenotypic heterogeneity might be diluting the COMT effect. To clarify the putative association, we performed an exploratory analysis to test for...

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Source

Identifiers

PMID: 16921496
DOI: 10.1002/ajmg.b.30401

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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