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Article

Vitamin D insufficiency and schizophrenia risk: evaluation of hyperprolinemia as a mediator of association.

Schizophrenia research - 1 Jun 2014

Clelland James D, Read Laura L, Drouet Valérie, Kaon Angela, Kelly Alexandra, Duff Karen E, Nadrich Robert H, Rajparia Amit, Clelland Catherine L

Abstract excerpt

25-Hydroxyvitamin D (25(OH)D) deficits have been associated with schizophrenia susceptibility and supplementation has been recommended for those at-risk. Although the mechanism by which a deficit confers risk is unknown, vitamin D is a potent transcriptional modulator and can regulate proline dehydrogenase (PRODH) expression. PRODH maps to chromosome 22q11, a region conferring the highest known genetic risk of...

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Identifiers

PMID: 24787057
DOI: 10.1016/j.schres.2014.03.017
PMCID: PMC4044915

Genes

PRODH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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