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Article

Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia.

Genes, brain, and behavior - 1 Feb 2008

Zinkstok J, Schmitz N, van Amelsvoort T, Moeton M, Baas F, Linszen D

Abstract excerpt

Haploinsufficiency of 22q11 genes including catechol-O-methyltransferase (COMT) and proline dehydrogenase (PRODH) may result in structural and functional brain abnormalities and increased vulnerability to schizophrenia as observed in patients with microdeletions of 22q11. Thus, COMT and PRODH cou...

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Share to Catechol O-Methyltransferase
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Share to Chromosomes, Human, Pair 22

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17504246
DOI: 10.1111/j.1601-183X.2007.00326.x

Genes

COMT
PRODH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17504246-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia.PMID 17504246Read ↗

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PRODH polymorphisms, cortical volumes and thickness in schizophrenia.Semantic proximity Read ↗

Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice.Semantic proximity Read ↗

Relationship of catechol-O-methyltransferase variants to brain structure and function in a population at high risk of psychosis.Semantic proximity Read ↗

Neuroimaging and molecular genetics of schizophrenia: pathophysiological advances and therapeutic potential.Semantic proximity Read ↗

Impact of interacting functional variants in COMT on regional gray matter volume in human brain.Semantic proximity Read ↗

Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia.Semantic proximity Read ↗

Effects of COMT polymorphisms on brain function and behavior in health and disease.Semantic proximity Read ↗

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