Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of association between the catechol-O-methyltransferase (COMT) gene and negative symptoms in chronic schizophrenia.

Psychiatry research - 30 Sept 2010

Wang Yan, Fang Yue, Shen Yan, Xu Qi

Abstract excerpt

Negative symptoms commonly seen in chronic schizophrenia are related to prefrontal hypodopaminergia. Dysfunction of the catechol-O-methyltransferase (COMT) gene has long been thought to confer susceptibility to schizophrenia because of its catalytic activity for dopamine degradation. The present study is an attempt to perform a quantitative trait test for genetic association between the COMT gene and negative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catechol O-Methyltransferase
Share to Chi-Square Distribution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genome-Wide Association Study

Share to Genotype

Share to Polymorphism, Single Nucleotide

Share to Psychiatric Status Rating Scales

Share to Schizophrenia

Source

Identifiers

PMID: 20483479
DOI: 10.1016/j.psychres.2009.03.029

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of association between the catechol-O-methyltransferase (COMT) gene and negative symptoms in chronic schizophrenia.PMID 20483479Read ↗

Association of catechol-O-methyltransferase gene polymorphisms with schizophrenia and negative symptoms in a Chinese population.Semantic proximity Read ↗

The effects of catechol-O-methyltransferase single nucleotide polymorphisms on positive and negative symptoms of schizophrenia: A systematic review and meta-analysis.Semantic proximity Read ↗

Association between COMT gene polymorphisms, clinical symptoms, and cognitive functions in Han Chinese patients with schizophrenia.Semantic proximity Read ↗

Association study of catechol-O-methyltransferase gene polymorphisms with schizophrenia and psychopathological symptoms in Han Chinese.Semantic proximity Read ↗

The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia.Semantic proximity Read ↗

Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study.Semantic proximity Read ↗

[An association study of COMT gene polymorphisms with schizophrenia].Semantic proximity Read ↗

Association between a COMT polymorphism and clinical response to risperidone treatment: a pharmacogenetic study.Semantic proximity Read ↗

Sex-dependent effect on the association of COMT Val158Met polymorphism with schizophrenia clinical symptoms and cognitive impairmentSemantic proximity Read ↗

Association of the 3' region of COMT with schizophrenia in Taiwan.Semantic proximity Read ↗

Associations between Catechol-O-methyltransferase (COMT) polymorphisms and cognitive impairments, psychiatric symptoms and tardive dyskinesia in schizophrenia.Semantic proximity Read ↗

Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.