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Article

Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice.

Nature neuroscience - 1 Nov 2005

Paterlini Marta, Zakharenko Stanislav S, Lai Wen-Sung, Qin Jie, Zhang Hui, Mukai Jun, Westphal Koen G C, Olivier Berend, Sulzer David, Pavlidis Paul, Siegelbaum Steven A, Karayiorgou Maria, Gogos Joseph A

Abstract excerpt

Microdeletions of 22q11.2 represent one of the highest known genetic risk factors for schizophrenia. It is likely that more than one gene contributes to the marked risk associated with this locus. Two of the candidate risk genes encode the enzymes proline dehydrogenase (PRODH) and catechol-O-methyltransferase (COMT), which modulate the levels of a putative neuromodulator (L-proline) and the neurotransmitter...

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Source

Identifiers

PMID: 16234811
DOI: 10.1038/nn1562

Genes

PRODH
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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