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Article

Proline affects brain function in 22q11DS children with the low activity COMT 158 allele.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Feb 2009

Vorstman Jacob A S, Turetsky Bruce I, Sijmens-Morcus Monique E J, de Sain Monique G, Dorland Bert, Sprong Mirjam, Rappaport Eric F, Beemer Frits A, Emanuel Beverly S, Kahn René S, van Engeland Herman, Kemner Chantal

Abstract excerpt

The association between the 22q11.2 deletion syndrome (22q11DS) and psychiatric disorders, particularly psychosis, suggests a causal relationship between 22q11DS genes and abnormal brain function. The genes catechol-O-methyl-transferase (COMT) and proline dehydrogenase both reside within the comm...

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Source

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Identifiers

PMID: 18769474
DOI: 10.1038/npp.2008.132
PMCID: PMC2817942

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18769474-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Proline affects brain function in 22q11DS children with the low activity COMT 158 allele.PMID 18769474Read ↗

PRODH rs450046 and proline x COMT Val¹⁵⁸ Met interaction effects on intelligence and startle in adults with 22q11 deletion syndrome.Semantic proximity Read ↗

The role of COMT and plasma proline in the variable penetrance of autistic spectrum symptoms in 22q11.2 deletion syndrome.Semantic proximity Read ↗

Startle reactivity and prepulse inhibition of the acoustic startle response are modulated by catechol-O-methyl-transferase Val(158) Met polymorphism in adults with 22q11 deletion syndrome.Semantic proximity Read ↗

COMT Val108/158 Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome.Semantic proximity Read ↗

Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice.Semantic proximity Read ↗

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Evidence that COMT genotype and proline interact on negative-symptom outcomes in schizophrenia and bipolar disorder.Semantic proximity Read ↗

Schizophrenia-like neurophysiological abnormalities in 22q11.2 deletion syndrome and their association to COMT and PRODH genotypes.Semantic proximity Read ↗

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