Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The relationship between COMT, proline, and negative symptoms in clinical high risk and recent psychosis onset.

Translational psychiatry - 2 Oct 2024

Clelland James D, Hesson Hannah, Ramiah Krista, Anderson Julia, Thengampallil Abraham, Girgis Ragy R, Clelland Catherine L

Abstract excerpt

Individuals at clinical high-risk (CHR) of developing psychosis, as well as patients with recent psychosis onset (RO), experience significant negative symptoms that detrimentally impact daily-life functioning and are associated with poor outcomes, even in those who do not convert to psychosis. Targeting negative symptoms may thus hold promise for the treatment of CHR and RO patients. Building from previous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to Polymorphism, Single Nucleotide

Share to Proline

Share to Psychotic Disorders

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 39358340
DOI: 10.1038/s41398-024-03099-0
PMCID: PMC11447206

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The relationship between COMT, proline, and negative symptoms in clinical high risk and recent psychosis onset.PMID 39358340Read ↗

Evidence that COMT genotype and proline interact on negative-symptom outcomes in schizophrenia and bipolar disorder.Semantic proximity Read ↗

A proof-of-concept study: Investigating the impact of<i>COMT</i>genotype and proline on negative symptoms in Alzheimer’s DiseaseSemantic proximity Read ↗

COMT Val158Met-stress interaction in psychosis: role of background psychosis risk.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met polymorphism and clinical characteristics in first episode non-affective psychosis.Semantic proximity Read ↗

PRODH rs450046 and proline x COMT Val¹⁵⁸ Met interaction effects on intelligence and startle in adults with 22q11 deletion syndrome.Semantic proximity Read ↗

Positive symptoms in first-episode psychosis patients experiencing low maternal care and stressful life events: a pilot study to explore the role of the COMT gene.Semantic proximity Read ↗

Catechol-O-methyltransferase and the clinical features of psychosis.Semantic proximity Read ↗

Differential association of the COMT Val158Met polymorphism with clinical phenotypes in schizophrenia and bipolar disorder.Semantic proximity Read ↗

Symptom Dimension-Specific Neurotransmitter Correlates of Psychopathology and Cognition in Early PsychosisSemantic proximity Read ↗

Exploring the indirect effects of catechol-O-methyltransferase (COMT) genotype on psychotic experiences through cognitive function and anxiety disorders in a large birth cohort of children.Semantic proximity Read ↗

The role of stress-regulation genes in moderating the association of stress and daily-life psychotic experiences.Semantic proximity Read ↗

Proline affects brain function in 22q11DS children with the low activity COMT 158 allele.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.