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A proof-of-concept study: Investigating the impact of<i>COMT</i>genotype and proline on negative symptoms in Alzheimer’s Disease

2025-05-15

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<h4>Summary</h4> Previous studies have reported that levels of fasting plasma proline and catechol-O-methyltransferase ( COMT ) Val 158 Met genotype influence negative symptoms in patients with severe psychiatric illness and those at-risk for psychosis. Parallel negative neuropsychiatric symptoms are also a core feature of Alzheimer’s disease (AD). In this proof-of-concept cross-sectional study of dementia patient...

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Literature Corpus work
833360ee-8cb2-5225-9e78-c57131b16b50
DOI
10.1101/2025.05.15.25327175
Open publication

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A proof-of-concept study: Investigating the impact of<i>COMT</i>genotype and proline on negative symptoms in Alzheimer’s DiseaseDOI 10.1101/2025.05.15.25327175
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