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Article

PRODH rs450046 and proline x COMT Val¹⁵⁸ Met interaction effects on intelligence and startle in adults with 22q11 deletion syndrome.

Psychopharmacology - 1 Sept 2015

de Koning Mariken B, van Duin Esther D A, Boot Erik, Bloemen Oswald J N, Bakker Jaap A, Abel Kathryn M, van Amelsvoort Thérèse A M J

Abstract excerpt

RATIONALE: 22q11 deletion syndrome (22q11DS) is associated with an increased risk for psychotic disorders, suggesting a relationship between genotypes and the pathophysiology of psychotic disorders. Two genes in the deleted region, catechol-O-methyl-transferase (COMT) and proline dehydrogenase (oxidase) 1 (PRODH), contain polymorphisms associated with neuropsychiatric phenotypes. OBJECTIVES: Here, we explored the...

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Source

Identifiers

PMID: 26068888
DOI: 10.1007/s00213-015-3971-5

Genes

COMT
PRODH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PRODH rs450046 and proline x COMT Val¹⁵⁸ Met interaction effects on intelligence and startle in adults with 22q11 deletion syndrome.PMID 26068888Read ↗

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