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Article

CHRNA4 and ANKK1 Polymorphisms Influence Smoking-Induced Nicotinic Acetylcholine Receptor Upregulation.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 1 Sept 2016

Esterlis Irina, Hillmer Ansel T, Bois Frederic, Pittman Brian, McGovern Erin, O'Malley Stephanie S, Picciotto Marina R, Yang Bao-Zhu, Gelernter Joel, Cosgrove Kelly P

Abstract excerpt

INTRODUCTION: Tobacco smoking leads to increased numbers of β2*-containing nicotinic acetylcholine receptors (β2*-nAChRs) throughout the brain, which return to nonsmoker levels over extended abstinence. The goal of the current study was to determine whether the degree of tobacco smoking-induced changes in β2*-nAChR availability is genetically influenced. METHODS: In this study, 113 European Americans participated...

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Source

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Identifiers

PMID: 27611310
DOI: 10.1093/ntr/ntw081
PMCID: PMC4978979

Genes

CHRNA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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