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Article

Macrophage Susceptibility to Emactuzumab (RG7155) Treatment.

Molecular cancer therapeutics - 1 Dec 2016

Pradel Leon P, Ooi Chia-Huey, Romagnoli Solange, Cannarile Michael A, Sade Hadassah, Rüttinger Dominik, Ries Carola H

Abstract excerpt

Blockade of colony-stimulating factor-1 receptor (CSF-1R) enables the therapeutic targeting of tumor-associated macrophages (TAM) in cancer patients. Various CSF-1R inhibitors, mAbs, and tyrosine kinase inhibitors are currently evaluated in early clinical trials. Presence of an alternative survival signal, such as GM-CSF, rescues human monocyte-derived macrophages from CSF-1R inhibitor-induced apoptosis. In this...

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PMID: 27582524
DOI: 10.1158/1535-7163.MCT-16-0157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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