Article

Critical role of CD206+ macrophages in promoting a cDC1-NK-CD8 T cell anti-tumor immune axis

2023-11-02

Abstract excerpt

Tumor-associated macrophages (TAMs) are frequently categorized as being ‘M1’ or ‘M2’ polarized, even as substantial data challenges this binary modeling of macrophage cell state. One molecule consistently referenced as a delineator of a putative immunosuppressive ‘M2’ state is the surface protein CD206. We thus made a novel conditional CD206 ( Mrc1 ) knock-in mouse to specifically visualize and/or deplete CD206+...

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Literature Corpus work: 84fd878d-de45-5592-ac26-b7309f92014e
DOI: 10.1101/2023.10.31.560822

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