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Article

A novel Chimeric Antigen Receptor (CAR) - strategy to target EGFRVIII-mutated glioblastoma cells via macrophages.

BMC cancer - 8 May 2026

Vera Kristi, Esken Gülen, Hwang Jin Wook, Elbaz Carine, Chaker Diana, Oudrhiri Noufissa, Desterke Christophe, Griscelli Frank, Bennaceur-Griscelli Annelise, Turhan Ali G

Abstract excerpt

BACKGROUND: Autologous chimeric antigen receptor (CAR) expressing T-Cells (CAR-T) have been efficiently used in hematological malignancies but their efficacy in solid tumors remains limited. CAR therapies via the use of macrophages, offer a promising avenue due to their unique ability to infiltrate tumors and to initiate phagocytosis. METHODS: To generate a preclinical model of CAR-Macs, we have designed a novel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42104273
DOI: 10.1186/s12885-026-16080-5
PMCID: PMC13321683

Genes

MEGF10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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