Article

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

2024-05-05

Abstract excerpt

Tumor-associated macrophages exhibit high heterogeneity and contribute to the establishment of an immunosuppressive tumor microenvironment (TME). Although numerous studies have demonstrated that extracellular factors promote macrophage proliferation and polarization, the regulatory mechanisms governing the differentiation process to generate phenotypically, and functionally diverse macrophage subpopulations remain...

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Literature Corpus work: 90d5fad0-ab52-5bd2-bd63-bd029b85a898
DOI: 10.1101/2024.05.03.592354

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