Article

TRAIL promotes the polarization of human macrophages toward a proinflammatory M1 phenotype and is associated with increased survival in cancer patients with high tumor macrophage content

2023-08-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> TNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can either induce cell death or activate survival pathways after binding to death receptors (DRs) DR4 or DR5. TRAIL is investigated as a therapeutic agent in clinical trials due to its selective toxicity to transformed cells. Macrophages can be polarized into pro-inflammatory/tumor-fighting...

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Literature Corpus work: fcc38721-bea6-52fa-aeaf-369c2ad3647b
DOI: 10.1101/2023.08.16.553509

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